The data.frame has to be structured as follows

1st column: label of the drugs

2nd column: label of the adverse events

3rd column: Number of spontaneous reports of the corresponding couple drug-adverse event.

This option can be used to eliminate the drugs and the adverse events for which the marginal counts are less than MARGIN.THRES.

data.frame that contains the labels of the drugs and the adverse events.

sum of the spontaneous reports counts.

data.frame that contains the number of spontaneous reports (n11) and the corresponding marginal counts as well (n1. and n.1).