Normalised prediction distribution errors for nonlinear mixed-effect models
Routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics
Emmanuelle Comets, Karl Brendel, Thi Huyen Tram Nguyen, France Mentre
Maintainer: Emmanuelle Comets <emmanuelle.comets@bichat.inserm.fr>
K. Brendel, E. Comets, C. Laffont, C. Laveille, and F. Mentr\'e. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide. Pharmaceutical Research, 23:2036–49, 2006.
PDF documentation for npde 3.0: https://github.com/ecomets/npde30/blob/main/userguide_npde_3.0.pdf
data(theopp) data(simtheopp) # Calling autonpde with dataframes x<-autonpde(theopp,simtheopp,ix="Time",iy="Conc",iid="ID",boolsave=FALSE) print(x)
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