Provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics. Documentation about 'npde' is provided by a comprehensive user guide on the github repository (<https://github.com/ecomets/npde30/blob/main/userguide_npde_3.0.pdf>), and references concerning the methods include the papers by Brendel et al. (2006, <doi:10.1007/s11095-006-9067-5>; 2010, <doi:10.1007/s10928-009-9143-7>), Comets et al. (2008, <doi:10.1016/j.cmpb.2007.12.002> ; 2010, <http://journal-sfds.fr/article/view/45>), and Nguyen et al. (2012, <doi:10.1007/s10928-012-9264-2>). See 'citation("npde")' for details.

Normalised Prediction Distribution Errors for Nonlinear
Mixed-Effect Models

package-ubuntu-20.04-r-4.0.5#cran#npde-3.1

<p>Main npde function, used to compute pd and npde
</p>

<table summary="R argblock"><tr valign="top">
<td><code>object</code></td>
<td>
<p>A NpdeObject object</p>
</td>
</tr></table>

<p>A NpdeObject object updated with the results
</p>

package-ubuntu-20.04-r-4.0.5#cran#npde-3.1#docs#npde.main

npde.main

Description

Usage

Arguments

Value

npde

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