BisqueRNA: SimulateData – R documentation

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SimulateData

Simulate data for decomposition illustration

Description

Simulates bulk and single-cell expression, as well as marker genes and true proportions that can be used as an example of decomposition

Usage

SimulateData(n.ind, n.genes, n.cells, cell.types, avg.props)

Arguments

`n.ind`	Integer. Number of individuals to simulate
`n.genes`	Integer. Number of genes to simulate
`n.cells`	Integer. Number of cells per individual for single-cell data
`cell.types`	Character vector. List of cell types to simulate
`avg.props`	Numeric vector. List of average proportions for given cell types. Should be same length as cell.types and sum to 1

Value

A list with simulated single-cell in slot 'sc.eset' and bulk in 'bulk.eset', as well as true proportions in 'props' and marker genes in 'markers'.

Examples

library(Biobase)
sim.data <- SimulateData(n.ind=10, n.genes=100, n.cells=100,
                         cell.types=c("Neurons", "Astrocytes", "Microglia"),
                         avg.props=c(.5, .3, .2))

BisqueRNA

Decomposition of Bulk Expression with Single-Cell Sequencing

v1.0.4

GPL-3

Authors

Brandon Jew [aut, cre], Marcus Alvarez [aut]

Initial release