OncoBayes2

OncoBayes2

Bind rows of multiple data frames with zero fill

Bayesian Logistic Regression Model for N-compounds with EXNEX

Build a BLRM formula with linear interaction term in logit-space

Build a BLRM formula with saturating interaction term in logit-space

Dose-Escalation Trials guided by Bayesian Logistic Regression Model

Dataset: historical and concurrent data on a two-way combination

Dataset: trial dose information for a dual-agent combination study

extracts from a blrmfit object and a given data-set the group and stratum factor

Utility function to label parameter indices according to factor levels.

Backport from R 4

Backport from R 4

Test if each group is assigned to exactly 1 stratum. Error otherwise.

Dataset: drug information for a dual-agent combination study

Two-drug combination example

Two-drug combination example using BLRM Trial

Three-drug combination example

Single Agent Example

Runs example models

Single-agent example

Dataset: historical data on two single-agents to inform a combination study

Dataset: historical and concurrent data on a three-way combination

Logit (log-odds) and inverse-logit function.

Numerically stable summation of log inv logit

Numerically stable mean of logs

Numerically stable summation of logs

Return the number of posterior samples

Plot a fitted model

Posterior intervals

Posterior of linear predictor

Posterior of predictive

Internal function to simulate from the posterior new parameter draws

Posterior predictive intervals

Summarise model prior

Summarise trial

Summarise model results

Update data and/or prior of a BLRM trial

Update data of a BLRM analysis