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addat

Data on NSAID and antidepressant exposure and first GI bleed


Description

The data comprise ages in days at first gastro-intestinal (GI) bleed, treatments with non-steroidal anti-inflammatory drugs (NSAIDs), and treatments with antidepressants (SDs). There are 1000 simulated cases based on Tata et al (2005).

Usage

addat

Format

A data frame containing 3628 rows and 8 columns. The column names are 'case' (individual identifier), 'sta' (age on the first day of the observation period), 'end' (age on last day of the observation period), 'bleed' (age at first GI bleed), 'ns' (age at first day of NSAID treatment episode), 'endns' (age at last day of NSAID treatment episode), 'ad' (age at first day of AD treatment episode), 'endad' (age on last day of AD treatment episode). The data are in format 'stack' (see dataformat for details) with different exposure episodes on different rows.

References

Tata, L.J., Fortun, P. J., Hubbard, R. B., Smeeth, L., Hawkey, C. J., Smith, P., Whitaker, H. J., Farrington, C. P., Card, T. R. and West J. (2005). Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding? Alimentary Pharmacology and Therapeutics 22, 175–181.


SCCS

The Self-Controlled Case Series Method

v1.2
GPL (>= 2)
Authors
Yonas Ghebremichael Weldeselassie, Heather Whitaker, Paddy Farrington
Initial release
2020-09-30

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