bigsnpr: coef_to_liab – R documentation

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coef_to_liab

Liability scale

Coefficient to convert to the liability scale. E.g. h2_liab = coef * h2_obs.

coef_to_liab(K_pop, K_gwas = 0.5)

`K_pop`	Prevalence in the population.
`K_gwas`	Prevalence in the GWAS. You should provide this if you used (`n_case + n_control`) as sample size. If using the effective sample size `4 / (1 / n_case + 1 / n_control)` instead, you should keep the default value of `K_gwas = 0.5` as the GWAS case-control ascertainment is already accounted for in the effective sample size.

Scaling coefficient to convert e.g. heritability to the liability scale.

h2 <- 0.2
h2 * coef_to_liab(0.02)

Analysis of Massive SNP Arrays

v1.10.8

GPL-3

Authors

Florian Privé [aut, cre], Michael Blum [ths], Hugues Aschard [ths], Bjarni Jóhann Vilhjálmsson [ths]

Initial release

2022-07-05