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predict.emaxsimobj

Mean response and SE for specified doses for a simulated emaxsimobj object


Description

Estimated mean/proportion and standard error for specified doses computed from the output of a simulated data set created by function emaxsim. Also returns mean difference with placebo and their standard errors.

Usage

## S3 method for class 'emaxsimobj'
predict(object, 
          dose, dref=0,
          ...)

Arguments

object

Output of the extract function [] applied to an object createad by emaxsim.

dose

Vector (can be a single value) of doses where dose response curve is to be evaluated.

dref

A reference dose (0 by default) for contrasts, but other values can be specified. If specified, a single reference value must be given.

...

Optional arguments are not used.

Value

A list containing:

fitpred

Vector with mean dose response estimate for each specified dose.

fitdif

Corresponding differences with placebo.

sepred

SEs for fitpred.

sedif

SEs for fitdif.

Author(s)

Neal Thomas

See Also

Examples

## Not run: 
## emaxsim changes the random number seed
nsim<-50
idmax<-5
doselev<-c(0,5,25,50,100)
n<-c(78,81,81,81,77)

### population parameters for simulation
e0<-2.465375 
ed50<-67.481113 

dtarget<-100
diftarget<-9.032497
emax<-solveEmax(diftarget,dtarget,log(ed50),1,e0)

sdy<-7.967897
pop.parm<-c(log(ed50),emax,e0)    
meanlev<-emaxfun(doselev,pop.parm)  

###FixedMean is specialized constructor function for emaxsim
gen.parm<-FixedMean(n,doselev,meanlev,sdy)  
D1 <- emaxsim(nsim,gen.parm)
d10<-D1[10]
predict(d10,c(75,150))

## End(Not run)

clinDR

Simulation and Analysis Tools for Clinical Dose Response Modeling

v2.3.5
GPL (>= 2)
Authors
Neal Thomas [aut, cre] (<https://orcid.org/0000-0002-1915-8487>), Jing Wu [aut], Mike K. Smith [aut]
Initial release
2021-04-11

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