Size based on maximum of multiple cohort size rules
This class can be used to combine multiple cohort size rules with the MAX operation.
cohortSizeList contains all cohort size rules, which are again
objects of class CohortSize. The maximum of these
individual cohort sizes is taken to give the final cohort size.
cohortSizeListlist of cohort size rules
# Rule for having cohort of size 1 for doses <30
# and having cohort of size 3 for doses >=30
mySize1 <- CohortSizeRange(intervals = c(0, 10),
cohortSize = c(1, 3))
# Rule for having cohort of size 1 until no DLT were observed
# and having cohort of size 3 as soon as 1 DLT is observed
mySize2 <- CohortSizeDLT(DLTintervals=c(0, 1),
cohortSize=c(1, 3))
# Create a list of cohort size rules of class 'CohortSizeMax' which will then be
# combined with the 'max' operation
mySize <- CohortSizeMax(cohortSizeList=list(mySize1,
mySize2))Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.