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DataMixture-class

Class for the data with mixture sharing


Description

Class for the data with mixture sharing

Slots

xshare

the doses for the share patients

yshare

the vector of toxicity events (0 or 1 integers) for the share patients

nObsshare

number of share patients

See Also

LogisticLogNormalMixture for the explanation how to use this data class

Examples

## decide on the dose grid:
doseGrid <- 1:80

## and MCMC options:
options <- McmcOptions()

## the classic model would be:
model <- LogisticLogNormal(mean = c(-0.85, 1),
                           cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2),
                           refDose = 50)

nodata <- Data(doseGrid=doseGrid)

priorSamples <- mcmc(nodata, model, options)
plot(priorSamples, model, nodata)

## set up the mixture model and data share object:
modelShare <- LogisticLogNormalMixture(shareWeight=0.1,
                                       mean = c(-0.85, 1),
                                       cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2),
                                       refDose = 50)

nodataShare <- DataMixture(doseGrid=doseGrid,
                           xshare=
                             c(rep(10, 4),
                               rep(20, 4),
                               rep(40, 4)),
                           yshare=
                             c(rep(0L, 4),
                               rep(0L, 4),
                               rep(0L, 4)))

## now compare with the resulting prior model:
priorSamplesShare <- mcmc(nodataShare, modelShare, options)
plot(priorSamplesShare, modelShare, nodataShare)

crmPack

Object-Oriented Implementation of CRM Designs

v1.0.0
GPL (>= 2)
Authors
Daniel Sabanes Bove [aut], Wai Yin Yeung [aut], Giuseppe Palermo [aut, cre], Thomas Jaki [aut]
Initial release

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