The class with the input for finding the next dose in target interval
Note that to avoid numerical problems, the dose selection algorithm has been
implemented as follows: First admissible doses are found, which are those
with probability to fall in overdose category being below
maxOverdoseProb. Next, within the admissible doses, the maximum
probability to fall in the target category is calculated. If that is
above 5% (i.e., it is not just numerical error), then the corresponding
dose is the next recommended dose. Otherwise, the highest admissible dose is
the next recommended dose.
targetthe target toxicity interval (limits included)
overdosethe overdose toxicity interval (lower limit excluded, upper limit included)
maxOverdoseProbmaximum overdose probability that is allowed
# In the example below, the target toxiciy interval [0.2, 0.35] while the
# overdose interval is (0.35,1]. Finally we would like to constrain the probability
# of overdosing below 25%.
myNextBest <- NextBestNCRM(target=c(0.2, 0.35),
overdose=c(0.35, 1),
maxOverdoseProb=0.25)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.