Stop based on MTD distribution
Has 90% probability above a threshold of 50% of the current MTD been reached? This class is used for this question.
targetthe target toxicity probability (e.g. 0.33) defining the MTD
threshthe threshold relative to the MTD (e.g. 0.5)
probrequired probability (e.g. 0.9)
# As example, here is the rule for:
# stopping the study if there is at least 0.9 probability that MTD > 0.5*next_dose.
# Here MTD is defined as the dose for which prob(DLE)=0.33
myStopping <- StoppingMTDdistribution(target = 0.33,
thresh = 0.5,
prob = 0.9)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.