"MIN" combination of cohort size rules
This function combines cohort size rules by taking the minimum of all sizes.
minSize(...) ## S4 method for signature 'CohortSize' minSize(...)
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Objects of class |
the combination as an object of class
CohortSizeMin
CohortSize
: The method combining cohort size rules by taking minimum
# Here is the rule for: # having cohort of size 1 for doses <30 # and having cohort of size 3 for doses >=30 mySize1 <- CohortSizeRange(intervals = c(0, 30), cohortSize = c(1, 3)) # Here is the rule for: # having cohort of size 1 until no DLT were observed # and having cohort of size 3 as soon as 1 DLT is observed mySize2 <- CohortSizeDLT(DLTintervals=c(0, 1), cohortSize=c(1, 3)) # This is combining the two rules above by taking the minimum of the sample sizes of # the single rules mySize <- minSize(mySize1, mySize2)
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