Increments control based on relative differences in terms of DLTs
Note that DLTintervals is to be read as follows. If for example,
we want to specify three intervals: First 0 DLTs, second 1 or 2 DLTs, and
third at least 3 DLTs, then we specify
DLTintervals to be c(0, 1, 3). That means, the right
bound of the intervals are exclusive to the interval – the vector only
gives the left bounds of the intervals. The last interval goes from 3 to
infinity.
DLTintervalsan integer vector with the left bounds of the relevant DLT intervals
incrementsa vector of the same length with the maximum allowable
relative increments in the DLTintervals
# As example, here is the rule for:
# maximum doubling the dose if no DLTs were observed at the current dose
# or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
# or maximum increasing the dose by 1.22 if 3 or more DLTs were observed
myIncrements <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
increments = c(1, 0.33, 0.2))Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.