Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Object-Oriented Implementation of CRM Designs

package-ubuntu-20.04-r-4.0.5#cran#crmPack-1.0.0

Initialization function for "NextBestNCRM"

NextBestNCRM(target, overdose, maxOverdoseProb)

<table summary="R argblock">
<tr valign="top">
<td><code>target</code></td>
<td>
see <code><a href="NextBestNCRM-class.html">NextBestNCRM</a></code>
</td>
</tr>
<tr valign="top">
<td><code>overdose</code></td>
<td>
see <code><a href="NextBestNCRM-class.html">NextBestNCRM</a></code>
</td>
</tr>
<tr valign="top">
<td><code>maxOverdoseProb</code></td>
<td>
see <code><a href="NextBestNCRM-class.html">NextBestNCRM</a></code>
</td>
</tr>
</table>

the <code><a href="NextBestNCRM-class.html">NextBestNCRM</a></code> object

package-ubuntu-20.04-r-4.0.5#cran#crmPack-1.0.0#docs#NextBestNCRM

`target`	see `NextBestNCRM`
`overdose`	see `NextBestNCRM`
`maxOverdoseProb`	see `NextBestNCRM`

NextBestNCRM

Description

Usage

Arguments

Value

crmPack

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