Next best dose based on Pseudo DLE model without sample
The class is to find the next best dose for allocation and the dose for final recommendation
at the end of a trial without involving any samples. This is a class for which only
DLE response will be incorporated for the dose-allocation.
This is only based on the probabilities of
the occurrence of a DLE obtained by using the modal estimates of the model paramters.
There are two inputs inputs which are the two target
probabilities of the occurrence of a DLE used during trial
and used at the end of trial, for finding the next best dose for allocation and the dose
for recommendation at the end of the trial.
It is only suitable to use with the model specified in ModelTox class.
targetDuringTrialthe target probability of the occurrrence of a DLE to be used during the trial
targetEndOfTrialthe target probability of the occurrence of a DLE to be used at the end of the trial. This target is particularly used to recommend the dose for which its posterior probability of the occurrence of a DLE is equal to this target
##define the NextBestTD class (no samples and based a pseudo DLE model)
##specified the target probability of the occurrence of a DLE during the trial be 0.35
##specified the target probability of the occurrence of a DLE at the end of trial be 0.3
myNextBest <-NextBestTD(targetDuringTrial=0.35,
targetEndOfTrial=0.3)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.