Stop based on probability of target biomarker
Stop based on probability of target biomarker
targetthe biomarker target range, that
needs to be reached. For example, (0.8, 1.0) and scale="relative"
means we target a dose with at least 80% of maximum biomarker level.
scaleeither relative (default, then the target is interpreted
relative to the maximum, so must be a probability range) or absolute
(then the target is interpreted as absolute biomarker range)
probrequired target probability for reaching sufficient precision
# As example, here is the rule for:
# stopping the study if there is at least 0.5 probability that the biomarker
# (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the
# maximum for the biomarker).
myStopping <- StoppingTargetBiomarker(target = c(0.9, 1),
prob = 0.5)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.