escalation: enforce_three_plus_three – R documentation

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enforce_three_plus_three

Enforce that a trial path has followed the 3+3 method.

Description

This function stops with en error if it detects that outcomes describing a trial path have diverged from that advocated by the 3+3 method.

Usage

enforce_three_plus_three(outcomes, allow_deescalate = FALSE)

Arguments

`outcomes`	Outcomes observed. See `parse_phase1_outcomes`.
`allow_deescalate`	TRUE to allow de-escalation, as described by Korn et al. Default is FALSE.

Value

Nothing. Function stops if problem detected.

Examples

## Not run: 
enforce_three_plus_three('1NNN 2NTN 2NNN')  # OK
enforce_three_plus_three('1NNN 2NTN 2N')  # OK too, albeit in-progress cohort
enforce_three_plus_three('1NNN 1N')  # Not OK because should have escalated

## End(Not run)

escalation

Modular Approach to Dose Finding Clinical Trials

v0.1.4

GPL (>= 3)

Authors

Kristian Brock [aut, cre] (<https://orcid.org/0000-0002-3921-0166>)

Initial release

2020-10-16