Toxicity rate limit
Get the maximum permissible toxicity rate, if supported. NULL if not.
tox_limit(x, ...)
x |
Object of type |
... |
Extra args are passed onwards. |
numeric
efftox_priors <- trialr::efftox_priors p <- efftox_priors(alpha_mean = -7.9593, alpha_sd = 3.5487, beta_mean = 1.5482, beta_sd = 3.5018, gamma_mean = 0.7367, gamma_sd = 2.5423, zeta_mean = 3.4181, zeta_sd = 2.4406, eta_mean = 0, eta_sd = 0.2, psi_mean = 0, psi_sd = 1) real_doses = c(1.0, 2.0, 4.0, 6.6, 10.0) model <- get_trialr_efftox(real_doses = real_doses, efficacy_hurdle = 0.5, toxicity_hurdle = 0.3, p_e = 0.1, p_t = 0.1, eff0 = 0.5, tox1 = 0.65, eff_star = 0.7, tox_star = 0.25, priors = p, iter = 1000, chains = 1, seed = 2020) x <- model %>% fit('1N 2E 3B') tox_limit(x)
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