httk: honda.ivive – R documentation

Become an expert in R — Interactive courses, Cheat Sheets, certificates and more!

honda.ivive

Return the assumptions used in Honda et al. 2019

Description

This function returns four of the better performing sets of assumptions evaluated in Honda et al. 2019 (https://doi.org/10.1371/journal.pone.0217564).These include four different combinations of hepatic clearance assumption, in vivo bioactivity assumption, and relevant tissue assumption. Generally, this function is not called directly by the user, but instead called by setting the IVIVE option in calc_mc_oral_equiv, calc_mc_css, and calc_analytic functions. Currently, these IVIVE option is not implemented the solve_1comp etc. functions.

Usage

honda.ivive(method = "Honda1", tissue = "liver")

Arguments

`method`	This is set to one of "Honda1", "Honda2", "Honda3", or "Honda4".
`tissue`	This is only relevant to "Honda4" and indicates the relevant tissue compartment.

Details

"Honda1" - tissue = NULL, restrictive.clearance = TRUE, bioactive.free.invivo = TRUE This assumption assumes restrictive hepatic clearance, and treats the free concentration in plasma as the bioactive concentration in vivo. This option must be used in combination with the concentration in vitro predicted by armitage_eval(), otherwise the result will be the same as "Honda2". This option corresponds to the result in Figure 8 panel c) restrictive, mean free plasma conc., Armitage in Honda et al. 2019. "Honda2" - tissue = NULL, restrictive.clearance = TRUE, bioactive.free.invivo = TRUE This assumption assumes restrictive hepatic clearance, and treats the free concentration in plasma as the bioactive concentration in vivo. This option corresponds to the result in Figure 8 panel b) restrictive, mean free plasma conc. in Honda et al. 2019. "Honda3" - tissue = NULL, restrictive.clearance = TRUE, bioactive.free.invivo = TRUE This assumption assumes restrictive hepatic clearance, and treats the free concentration in plasma as the bioactive concentration in vivo. This option corresponds to the result in Figure 8 panel a) restrictive, mean total plasma conc. in Honda et al. 2019. "Honda4" - tissue = tissue, restrictive.clearance = FALSE, bioactive.free.invivo = TRUE This assumption assumes restrictive hepatic clearance, and treats the free concentration in plasma as the bioactive concentration in vivo. The input tissue should be relevant to the in vitro assay endpoint used as input or that the result is being compared to. This option corresponds to the result in Figure 8 panel d) nonrestrictive, mean tissue conc. in Honda et al. 2019.

Value

A list of tissue, bioactive.free.invivo, and restrictive.clearance assumptions.

Author(s)

Greg Honda and John Wambaugh

References

Honda, Gregory S., et al. "Using the Concordance of In Vitro and In Vivo Data to Evaluate Extrapolation Assumptions." 2019. PLoS ONE 14(5): e0217564.

Examples

honda.ivive(method = "Honda1", tissue = NULL)

httk

High-Throughput Toxicokinetics

v2.0.4

GPL-3

Authors

John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb], Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)

Initial release

2021-05-07