httk: calc_hepatic_clearance – R documentation

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calc_hepatic_clearance

Calculate the hepatic clearance (deprecated).

Description

This function is included for backward compatibility. It calls calc_hep_clearance which calculates the hepatic clearance in plasma for a well-stirred model or other type if specified. Based on Ito and Houston (2004)

Usage

calc_hepatic_clearance(
  chem.name = NULL,
  chem.cas = NULL,
  dtxsid = NULL,
  parameters = NULL,
  species = "Human",
  default.to.human = FALSE,
  hepatic.model = "well-stirred",
  suppress.messages = FALSE,
  well.stirred.correction = TRUE,
  restrictive.clearance = TRUE,
  adjusted.Funbound.plasma = TRUE,
  ...
)

Arguments

`chem.name`	Either the chemical name, CAS number, or the parameters must be specified.
`chem.cas`	Either the chemical name, CAS number, or the parameters must be specified.
`dtxsid`	EPA's DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs
`parameters`	Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.
`species`	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
`default.to.human`	Substitutes missing animal values with human values if true.
`hepatic.model`	Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred.
`suppress.messages`	Whether or not to suppress the output message.
`well.stirred.correction`	Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for hepatic.model well-stirred. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.
`restrictive.clearance`	Protein binding not taken into account (set to 1) in liver clearance if FALSE.
`adjusted.Funbound.plasma`	Uses adjusted Funbound.plasma when set to TRUE.
`...`	Additional parameters passed to parameterize_steadystate if parameters is NULL.

Value

Hepatic Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh and Robert Pearce

References

Ito, K., & Houston, J. B. (2004). "Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes." Pharmaceutical Tesearch, 21(5), 785-792.

Examples

calc_hep_clearance(chem.name="Ibuprofen",hepatic.model='unscaled')
calc_hep_clearance(chem.name="Ibuprofen",well.stirred.correction=FALSE)

httk

High-Throughput Toxicokinetics

v2.0.4

GPL-3

Authors

John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb], Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)

Initial release

2021-05-07