httk: calc_krbc2pu – R documentation

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calc_krbc2pu

Back-calculates the Red Blood Cell to Unbound Plasma Partition Coefficient

Description

Given and observed ratio of chemial concentration in blood to plasma, this function calculates a Red Blood Cell to unbound plasma (Krbc2pu) partition coefficient that would be consistent with that observation.

Usage

calc_krbc2pu(
  Rb2p,
  Funbound.plasma,
  hematocrit = NULL,
  default.to.human = FALSE,
  species = "Human",
  suppress.messages = TRUE
)

Arguments

`Rb2p`	The chemical blood:plasma concentration ratop
`Funbound.plasma`	The free fraction of chemical in the presence of plasma protein Rblood2plasma.
`hematocrit`	Overwrites default hematocrit value in calculating Rblood2plasma.
`default.to.human`	Substitutes missing animal values with human values if true.
`species`	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
`suppress.messages`	Determine whether to display certain usage feedback.

Value

The red blood cell to unbound chemical in plasma partition coefficient.

Author(s)

John Wambaugh and Robert Pearce

References

Pearce, Robert G., et al. "Evaluation and calibration of high-throughput predictions of chemical distribution to tissues." Journal of pharmacokinetics and pharmacodynamics 44.6 (2017): 549-565.

Ruark, Christopher D., et al. "Predicting passive and active tissue: plasma partition coefficients: interindividual and interspecies variability." Journal of pharmaceutical sciences 103.7 (2014): 2189-2198.

httk

High-Throughput Toxicokinetics

v2.0.4

GPL-3

Authors

John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb], Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)

Initial release

2021-05-07