httk: httkpop_mc – R documentation

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httkpop_mc

Converts the HTTK-Pop population data table to a table of the parameters needed by HTTK, for a specific chemical.

Description

Takes the data table generated by httkpop_generate, and converts it to the corresponding table of HTTK model parameters for a specified chemical and HTTK model.

Usage

httkpop_mc(model, samples = 1000, httkpop.dt = NULL, ...)

Arguments

`model`	One of the HTTK models: "1compartment", "3compartmentss", "3compartment", or "pbtk".
`samples`	The number of Monte Carlo samples to use (can often think of these as separate individuals)
`httkpop.dt`	A data table generated by `httkpop_generate`. This defaults to NULL, in which case `httkpop_generate` is called to generate this table.
`...`	Additional arugments passed on to `httkpop_generate`.

Value

A data.table with a row for each individual in the sample and a column for each parater in the model.

Author(s)

Caroline Ring and John Wambaugh

References

Ring, Caroline L., et al. "Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability." Environment International 106 (2017): 105-118

Rowland, Malcolm, Leslie Z. Benet, and Garry G. Graham. "Clearance concepts in pharmacokinetics." Journal of Pharmacokinetics and Biopharmaceutics 1.2 (1973): 123-136.

Examples

set.seed(42)
indiv_examp <- httkpop_generate(method="d", nsamp=100)
httk_param <- httkpop_mc(httkpop.dt=indiv_examp, 
model="1compartment")

httk

High-Throughput Toxicokinetics

v2.0.4

GPL-3

Authors

John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb], Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)

Initial release

2021-05-07