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mcnally_dt

Reference tissue masses and flows from tables in McNally et al. 2014.

Description

Reference tissue masses, flows, and marginal distributions from McNally et al. 2014.

Usage

mcnally_dt

Format

A data.table with variables:

tissue

Body tissue

gender

Gender: Male or Female

mass_ref

Reference mass in kg, from Reference Man

mass_cv

Coefficient of variation for mass

mass_dist

Distribution for mass: Normal or Log-normal

flow_ref

Reference flow in L/h, from Reference Man

flow_cv

Coefficient of variation for flow (all normally distributed)

height_ref

Reference heights (by gender)

CO_ref

Reference cardiac output by gender

flow_frac

Fraction of CO flowing to each tissue: flow_ref/CO_ref

Author(s)

Caroline Ring

Source

McNally K, Cotton R, Hogg A, Loizou G. "PopGen: A virtual human population generator." Toxicology 315, 70-85, 2004.

References

Ring, Caroline L., et al. "Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability." Environment International 106 (2017): 105-118

httk

High-Throughput Toxicokinetics

v2.0.4
GPL-3
Authors
John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb], Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)
Initial release
2021-05-07

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