Description

This data set contains values from Schmitt (2008) and Ruark et al. (2014) describing the composition of specific tissues and from Birnbaum et al. (1994) describing volumes of and blood flows to those tissues, allowing parameterization of toxicokinetic models for human, mouse, rat, dog, or rabbit. Tissue volumes were calculated by converting the fractional mass of each tissue with its density (both from ICRP), lumping the remaining tissues into the rest-of-body, excluding the mass of the gastrointestinal contents

Usage

Format

A data.frame containing 13 rows and 20 columns.

Author(s)

John Wambaugh, Robert Pearce, and Nisha Sipes

Source

Pearce et al. (2017), in preparation,

Wambaugh, John F., et al. "Toxicokinetic triage for environmental chemicals." Toxicological Sciences (2015): 228-237.

References

Birnbaum, L and Brown, R and Bischoff, K and Foran, J and Blancato, J and Clewell, H and Dedrick, R (1994). Physiological parameter values for PBPK model. International Life Sciences Institute, Risk Science Institute, Washington, DC

Ruark, Christopher D., et al. "Predicting passive and active tissue: plasma partition coefficients: Interindividual and interspecies variability." Journal of pharmaceutical sciences 103.7 (2014): 2189-2198.

Schmitt, W. (2008). General approach for the calculation of tissue to plasma partition coefficients. Toxicology in vitro : an international journal published in association with BIBRA 22(2), 457-67, 10.1016/j.tiv.2007.09.010.

ICRP. Report of the Task Group on Reference Man. ICRP Publication 23 1975