Description

modlib: PK/PD Model parameters, compartments, and output variables

Compartments

• EV1, EV2: extravascular dosing compartments

• CENT: central PK compartment

• PERIPH: peripheral PK compartment

• PERIPH2: peripheral PK compartment 2

• RESP: response PD compartment (irm models)

Output variables

• CP: concentration in the central compartment (CENT/VC)

• RESP: response (emax model)

PK parameters

• KA1, KA2: first order absorption rate constants from first and second extravascular compartment (1/time)

• CL: clearance (volume/time)

• VC: volume of distribution, central compartment (volume)

• VP: volume of distribution, peripheral compartment (volume)

• VP2: volume of distribution, peripheral compartment 2 (volume)

• Q: intercompartmental clearance (volume/time)

• Q2: intercompartmental clearance 2 (volume/time)

• VMAX: maximum rate, nonlinear process (mass/time)

• KM: Michaelis constant (mass/volume)

• K10: elimination rate constant (1/time); CL/VC

• K12: rate constant for transfer to peripheral compartment from central (1/time); Q/VC

• K21: rate constant for transfer to central compartment from peripheral (1/time); Q/VP

PD parameters

• E0: baseline effect (emax model)

• EMAX, IMAX: maximum effect (response)

• EC50, IC50: concentration producing 50 percent of effect (mass/volume)

• KIN: zero-order response production rate (irm models) (response/time)

• KOUT: first-order response elimination rate (irm models) (1/time)

• n: sigmoidicity factor

• KEO: rate constant for transfer to effect compartment (1/time)