Description

modlib: HCV viral dynamics models

Models

• viral1: viral dynamics model with single HCV species

• viral2: viral dynamics model with wild-type and mutant HCV species

Parameters

• s: new hepatocyte synthesis rate (cells/ml/day)

• d: hepatocyte death rate constant (1/day)

• p: viral production rate constant (copies/cell/day)

• beta: new infection rate constant (ml/copy/day)

• delta: infected cell death rate constant (1/day)

• c: viral clearance rate constant (1/day)

• fit: mutant virus fitness

• N: non-target hepatocytes

• mu: forward mutation rate

• Tmax: maximum number of target hepatocytes (cells/ml)

• rho: maximum hepatocyte regeneration rate (1/day)

Compartments

• T: uninfected target hepatocytes (cells/ml)

• I: productively infected hepatocytes (cells/ml)

• V: hepatitis C virus (copies/ml)

• IM: mutant infected hepatocytes (cells/ml)

• VM: mutant hepatitis C virus (copies/ml)

• expos: exposure metric to drive pharmacodynamic model