Description

Data frame containing the mean off-time reduction in patients given dopamine agonists as adjunct therapy in Parkinson's disease, from 7 trials comparing four active drugs and placebo (Dias et al. 2011).

Usage

Format

A data frame with 15 rows and 7 variables:

studyn

numeric study ID

trtn

numeric treatment code (placebo = 1)

y

mean off-time reduction

se

standard error

n

sample size

diff

mean difference vs. treatment in reference arm

se_diff

standard error of mean difference, see details

Details

This dataset may be analysed using either an arm-based likelihood using y and se, or a contrast-based likelihood using diff and se_diff (or a combination of the two across different studies).

The contrast-based data is formatted as described in set_agd_contrast(). That is, for the chosen reference arm in each study, the mean difference diff is set to NA, and se_diff is set to the standard error se of the outcome on the reference arm.

References

Dias S, Welton NJ, Sutton AJ, Ades AE (2011). “NICE DSU Technical Support Document 2: A generalised linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials.” National Institute for Health and Care Excellence. http://nicedsu.org.uk/.