Description

Warfarin PK/PD data

Usage

Format

A data frame with 519 rows and 9 columns

id

Patient identifier (n=32)

time

Time [h]

amt

Total drug administered [mg]

dv

Warfarin concentrations [mg/L] or PCA measurement

dvid

Dependent identifier Information (cp: Dose or PK, pca: PCA, factor)

evid

Event identifier

wt

Weight [kg]

age

Age [yr]

sex

Gender (male or female, factor)

Source

Funaki T, Holford N, Fujita S (2018). Population PKPD analysis using nlmixr and NONMEM. PAGJA 2018

References

O'Reilly RA, Aggeler PM, Leong LS. Studies of the coumarin anticoagulant drugs: The pharmacodynamics of warfarin in man. Journal of Clinical Investigation 1963; 42(10): 1542-1551

O'Reilly RA, Aggeler PM. Studies on coumarin anticoagulant drugs Initiation of warfarin therapy without a loading dose. Circulation 1968; 38: 169-177.

See Also

Other nlmixr datasets: Bolus_1CPTMM, Bolus_1CPT, Bolus_2CPTMM, Bolus_2CPT, Infusion_1CPT, Oral_1CPT, Wang2007, pheno_sd, rats, theo_md, theo_sd