Description

This S4 union class describes what types of distribution may be fitted by the user in the optimalThreshold package.

Details

Five theoretical types of distribution fit are supported by the package internally (normal, log-normal, gamma, scaled t, and logistic). However, it is possible for the user to fit a personalized distribution using the fit function, and passing the result to one of the two main functions: trtSelThresh, and diagThresh. The 'undefined' type is used to indicate which distribution must be expressed as a function of the three others when estimating the optimal threshold of a treatment selection marker (see References for more details).

References

Blangero, Y, Rabilloud, M, Ecochard, R, and Subtil, F. A Bayesian method to estimate the optimal threshold of a marker used to select patients' treatment. Statistical Methods in Medical Research. 2019. Subtil, F, and Rabilloud, M. A Bayesian method to estimate the optimal threshold of a longitudinal marker. Biometrical Journal. 2010.

See Also

fit, trtSelThresh, and diagThresh.