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dominant

Example pedigree for linkage analysis


Description

Medical pedigree with 23 individuals of which 15 are genotyped with 650 SNP markers. Eleven family members are affected by a disease, showing an autosomal dominant inheritance pattern.

Usage

dominant

Format

A data frame with 23 rows and 1306 columns, describing the pedigree and marker data in pre-makeped format. The first 6 columns contain the pedigree structure and affection status, while the final 1300 columns hold the marker alleles.

  • FAMID. Family ID

  • ID. Individual ID

  • FID. Father ID

  • MID. Mother ID

  • SEX. Gender (male=1, female=2)

  • AFF. Affection status (unaffected=1, affected=2, unkonwn=0)

  • M1_1. First allele of marker 1

  • M1_2. Second allele of marker 1

  • ...

  • M650_1. First allele of marker 650

  • M650_2. Second allele of marker 650

All markers are SNPs, whose alleles are written as 1 and 2. Missing alleles are denoted by 0.

Examples

x = linkdat(dominant)
summary(x)

paramlink

Parametric Linkage and Other Pedigree Analysis in R

v1.1-2
GPL (>= 2)
Authors
Magnus Dehli Vigeland [aut, cre], Thore Egeland [ctb], Guro Doerum [ctb]
Initial release
2018-01-05

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