Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method
It calculates AUC and AUMC using linear-up log-down method
LogAUC(x, y)
x |
vector values of independent variable, usually time |
y |
vector values of dependent variable, usually concentration |
This function returns AUC and AUMC by linear-up log-down method.
AUC |
area under the curve |
AUMC |
area under the first moment curve |
Kyun-Seop Bae <k@acr.kr>
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.
LogAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"]) # Compare the last line with the above AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], down="Log")
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