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IntAUC

Calculate interval AUC

Description

It calculates interval AUC

Usage

IntAUC(x, y, t1, t2, Res, down = "Linear")

Arguments

x

vector values of independent variable, usually time
y

vector values of dependent variable, usually concentration
t1

start time for AUC
t2

end time for AUC
Res

result from IndiNCA function
down

either of "Linear" or "Log" to indicate the way to calculate AUC

Details

This calculates an interval (partial) AUC (from t1 to t2) with the given series of x and y. If t1 and/or t2 cannot be found within x vector, it interpolates according to the down option.

Value

return interval AUC value (scalar)

Author(s)

Kyun-Seop Bae <k@acr.kr>

References

  1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

  2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

  3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

  4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

See Also

Examples

Res = sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], 
           dose=320, concUnit="mg/L")
IntAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], t1=0.5, t2=11, Res)
pkr

Pharmacokinetics in R

v0.1.2
GPL-3
Authors
Kyun-Seop Bae [aut], Jee Eun Lee [aut]
Initial release
2018-06-04

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