Representing Chen's Design
Representing Chen's Design
chenRand(N, mti, p, K = 2)
N |
integer for the total sample size of the trial. |
mti |
maximum tolerated imbalance in patient numbers during the trial. |
p |
success probability of the biased coin (e.g. in Efron's Biased Coin Design). |
K |
number of treatment groups (e.g. K=2 if we compare one experimental against one control treatment). |
A vector with the allocation sequence for a clinical trial.
It will contain a zero (resp. 1) at position i, when patient i
is allocated to treatment A (resp. B).
Chen Yung-Pin (1999) Biased coin design with imbalance tolerance. Comm. in Stat., 15, 953-975.
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