trialr: efftox_params-class – R documentation

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efftox_params-class

Container class for parameters to fit the EffTox model in trialr.

Container class for parameters to fit the EffTox model in trialr.

efftox_params(
  real_doses,
  efficacy_hurdle,
  toxicity_hurdle,
  p_e,
  p_t,
  eff0,
  tox1,
  eff_star,
  tox_star,
  priors
)

`real_doses`	a vector of numbers.The doses under investigation. They should be ordered from lowest to highest and be in consistent units. E.g., to conduct a dose-finding trial of doses 10mg, 20mg and 50mg, use c(10, 20, 50).
`efficacy_hurdle`	Minimum acceptable efficacy probability. A number between 0 and 1.
`toxicity_hurdle`	Maximum acceptable toxicity probability. A number between 0 and 1.
`p_e`	Certainty required to infer a dose is acceptable with regards to being probably efficacious; a number between 0 and 1.
`p_t`	Certainty required to infer a dose is acceptable with regards to being probably tolerable; a number between 0 and 1.
`eff0`	Efficacy probability required when toxicity is impossible; a number between 0 and 1 (see Details).
`tox1`	Toxicity probability permitted when efficacy is guaranteed; a number between 0 and 1 (see Details).
`eff_star`	Efficacy probability of an equi-utility third point (see Details).
`tox_star`	Toxicity probability of an equi-utility third point (see Details).
`priors`	instance of class `efftox_priors`, the hyperparameters for normal priors on the six model parameters.