trialr: efftox_solve_p – R documentation

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efftox_solve_p

Calculate the p-index for EffTox utility contours

Description

Calculate the p-index for EffTox utility contours so that the neutral utility contour intersects the following points in the Prob(Efficacy) - Prob(Toxicity) plane: (eff0, 0), (1, tox1) and (eff_star, tox_star)

Usage

efftox_solve_p(eff0, tox1, eff_star, tox_star)

Arguments

`eff0`	Efficacy probability required when toxicity is impossible; a number between 0 and 1
`tox1`	Toxicity probability permitted when efficacy is guaranteed; a number between 0 and 1
`eff_star`	Efficacy probability of an equi-utility third point
`tox_star`	Toxicity probability of an equi-utility third point

Value

The p-index

References

Thall, Herrick, Nguyen, Venier & Norris. 2014, Effective sample size for computing prior hyperparameters in Bayesian phase I-II dose-finding

Examples

efftox_solve_p(0.5, 0.65, 0.7, 0.25)

trialr

Clinical Trial Designs in 'rstan'

v0.1.5

GPL (>= 3)

Authors

Kristian Brock [aut, cre] (<https://orcid.org/0000-0002-3921-0166>), Trustees of Columbia University [cph]

Initial release

2020-10-14