Find the Location of Maximum, Error Spending Approach
Calculate the location of maximal type I error of secondary endpoint.
ldInitLocPeak(alpha, tVec, cvec, type = 2, initIntvl = c(0.8, 4))
alpha |
type I error. |
tVec |
information vector. |
cvec |
primary group sequential boundary. |
type |
type of the test procedure for the secondary endpoint. O'Brien- Fleming (OBF) type error spending funciton is 1, Pocock (POC) type error spending funciton is 2. |
initIntvl |
computing paramter, a pair of numbers containing the end-points of the interval to be searched for the root. |
This function searches the location of maximal type I error of secondary endpoint by using the error spending approach.
location of maximum, a number between 1 and the number of interims.
Jiangtao Gou
Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74, 40-48.
ldSecondaryBoundary, initLocBeak
#require(mvtnorm) #require(ldbounds) #K <- 6; #tVec <- c(140,328,453,578,659,1080)/1080; #alpha = 0.025; #cvec.obf <- bounds(tVec,iuse=c(1),alpha=c(alpha)); #cvec <- cvec.obf$upper.bounds; #loc <- ldInitLocPeak(alpha,tVec,cvec,type=2,initIntvl=c(0.9,4))
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