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gsrsb

Group Sequential Refined Secondary Boundary

A gate-keeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Computations related to group sequential primary and secondary boundaries. Refined secondary boundaries are calculated for a gate-keeping test on a primary and a secondary endpoint in a group sequential design with multiple interim looks. The choices include both the standard boundaries and the boundaries using error spending functions. Version 1.0.0 was released on April 12, 2017. See Tamhane et al. (2018), "A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks", Biometrics, 74(1), 40-48.

Functions (18)

cdBoundary

Lower and Upper Bounds Generator

genCorrMat

Correlation Matrix Generator

initLocPeak

Find the Location of Maximum, Standard OBF and POC

ldInitLocPeak

Find the Location of Maximum, Error Spending Approach

ldNominalSig

Calculate Nominal Significance, Error Spending Approach

ldPrimaryBoundary

Calculate Primary Boundaries, the Error Spending Approach

ldSecControl

Difference between the Error Rate and Significance Level, the Error Spending Approach

ldSecondaryBoundary

Calculate Refined Secondary Boundary, Error Spending Approach

nominalSig

Calculate Nominal Significance, Standard Approach

primaryBoundary

Calculate Primary Boundaries, Standard Approach

primaryBoundaryVec

Calculate the Primary Boundaries

psbTeXtable

Summarize Primary and Refined Secondary Boundaries in a TeX table

refinedBoundary

Summarize Primary and Refined Secondary Boundaries, Nominal Significance

secControl

Difference between the Error Rate and Significance Level, Standard Approach

secondaryBoundary

Calculate the Refined Secondary Boundaries, Standard OBF and POC

secondaryBoundaryVec

Calculate Refined Secondary Boundaries and Nominal Significance

secondaryBoundaryVecLD

Calculate Refined Secondary Boundaries and Nominal Significance, the Error Spending Approach

secondaryBoundaryVecOrig

Calculate Refined Secondary Boundaries and Nominal Significance, Standard Approach

gsrsb

Group Sequential Refined Secondary Boundary

v1.1.1
GPL-3
Authors
Jiangtao Gou and Fengqing (Zoe) Zhang
Initial release
2019-06-24

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