gsrsb: ldPrimaryBoundary – R documentation

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gsrsb

ldPrimaryBoundary

Calculate Primary Boundaries, the Error Spending Approach

Description

Primary boundaries calculation of Lan-DeMets OBF and POC.

Usage

ldPrimaryBoundary(tVec, alpha, type = 1, initIntvl = c(0.8, 8))

Arguments

`tVec`	a vector of information, gammaVec = sqrt(tVec).
`alpha`	significance level
`type`	type of sequential procedure. OBF is 1, POC is 2.
`initIntvl`	paramter for function uniroot (two numbers)

Value

a vector of primary boundaries.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.