Become an expert in R — Interactive courses, Cheat Sheets, certificates and more!
Get Started for Free

ldSecControl

Difference between the Error Rate and Significance Level, the Error Spending Approach


Description

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

Usage

ldSecControl(ap, alpha, cvec, tVec, ExtrmLoc, type = 2)

Arguments

ap

significance level for the primary endpoint

alpha

targeted significance level for the secondary endpoint

cvec

a vector of calculated primary boundaries

tVec

a vector of information, gammaVec = sqrt(tVec)

ExtrmLoc

an integer between 1 and K, locate the maximum of type I error of secondary endpoint

type

type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.

See Also

secControl


gsrsb

Group Sequential Refined Secondary Boundary

v1.1.1
GPL-3
Authors
Jiangtao Gou and Fengqing (Zoe) Zhang
Initial release
2019-06-24

We don't support your browser anymore

Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.