gsrsb: ldSecControl – R documentation

Become an expert in R — Interactive courses, Cheat Sheets, certificates and more!

ldSecControl

Difference between the Error Rate and Significance Level, the Error Spending Approach

Description

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

Usage

ldSecControl(ap, alpha, cvec, tVec, ExtrmLoc, type = 2)

Arguments

`ap`	significance level for the primary endpoint
`alpha`	targeted significance level for the secondary endpoint
`cvec`	a vector of calculated primary boundaries
`tVec`	a vector of information, gammaVec = sqrt(tVec)
`ExtrmLoc`	an integer between 1 and K, locate the maximum of type I error of secondary endpoint
`type`	type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.