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nominalSig

Calculate Nominal Significance, Standard Approach


Description

Nominal significance for the secondary endpoint are calculated by using the standard (original) approach.

Usage

nominalSig(gammaVec, cvec)

Arguments

gammaVec

square root of information.

cvec

group sequential boundary.

Details

This function calculates he nominal significance level of any given boundary.

Value

nominal significance

Author(s)

Jiangtao Gou

References

O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. Biometrics 35, 549-556.

Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. Biometrika 64, 191-199.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74, 40-48.

See Also

ldNominalSig, secondaryBoundaryVecOrig

Examples

#require(mvtnorm)
#require(ldbounds)
#nSig <- nominalSig(gammaVec=c(sqrt(1/3),1),cvec=c(2.2,1.8))

gsrsb

Group Sequential Refined Secondary Boundary

v1.1.1
GPL-3
Authors
Jiangtao Gou and Fengqing (Zoe) Zhang
Initial release
2019-06-24

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