Calculate Nominal Significance, Standard Approach
Nominal significance for the secondary endpoint are calculated by using the standard (original) approach.
nominalSig(gammaVec, cvec)
gammaVec |
square root of information. |
cvec |
group sequential boundary. |
This function calculates he nominal significance level of any given boundary.
nominal significance
Jiangtao Gou
O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. Biometrics 35, 549-556.
Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. Biometrika 64, 191-199.
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74, 40-48.
ldNominalSig, secondaryBoundaryVecOrig
#require(mvtnorm) #require(ldbounds) #nSig <- nominalSig(gammaVec=c(sqrt(1/3),1),cvec=c(2.2,1.8))
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