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secControl

Difference between the Error Rate and Significance Level, Standard Approach


Description

Calculate the difference between the error rate and significance level for the secondary endpoint, standard (original) approach.

Usage

secControl(d, alpha, cvec, gammaVec, ExtrmLoc, type = 2)

Arguments

d

boundary of secondary endpoint at the final look (a number, d_(K))

alpha

targeted significance level for the secondary endpoint

cvec

a vector of calculated primary boundaries

gammaVec

square root of information

ExtrmLoc

an integer between 1 and K, locate the maximum of type I error of secondary endpoint

type

type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.

See Also

ldSecControl


gsrsb

Group Sequential Refined Secondary Boundary

v1.1.1
GPL-3
Authors
Jiangtao Gou and Fengqing (Zoe) Zhang
Initial release
2019-06-24

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