gsrsb: secControl – R documentation

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secControl

Difference between the Error Rate and Significance Level, Standard Approach

Description

Calculate the difference between the error rate and significance level for the secondary endpoint, standard (original) approach.

Usage

secControl(d, alpha, cvec, gammaVec, ExtrmLoc, type = 2)

Arguments

`d`	boundary of secondary endpoint at the final look (a number, d_(K))
`alpha`	targeted significance level for the secondary endpoint
`cvec`	a vector of calculated primary boundaries
`gammaVec`	square root of information
`ExtrmLoc`	an integer between 1 and K, locate the maximum of type I error of secondary endpoint
`type`	type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.