Description

Plan

Document

• Add a proper vignette detailing and exploring exact 3+3 calculations

Refactor

• Remove the $safety component of exact trials?

  • Perhaps this ought to be calculated 'on the fly' by the summary method.

  • On-the-fly calculation would postpone use of ordinalizer, in keeping with the pattern established already for (non-exact) simulations.

• Should summary(EXACT)$safety bear class 'safetytab'?

• Example for 'as.data.table.exact'

• What is role of G function in exact.R?

Extend

• Implement exact 3+3 variant with allow_deescalation=FALSE

• Implement rolling 6

• Allow an accelerated titration phase

  • Note that this requires access to graded toxicities at simulation time, and therefore constitutes a substantial challenge to the generalizability of this software design.

• Index sims$fits to exact outcomes in A[[D]] where appropriate

  • See the haystack function in exact.R

Robustify

• Tests comparing results from multiple CRAN packages