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precautionary

Safety Diagnostics for Dose-Escalation Trial Designs

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020b), "Retrospective analysis of a fatal dose-finding trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design" <arXiv:2012.05301>.

Functions (24)

as.data.table.exact

Convert an object of class c('exact','precautionary','simulations') to a data.table

as.data.table.precautionary

Convert an object of class c('precautionary','simulations') to a data.table

cohorts_of_n

Override cohorts_of_n to include latent toxicity tolerances

exact

A wrapper function supporting exact simulation of dose-escalation trials.

extend

Extend an existing simulation, using one of several stopping criteria

format.safetytab

Format a phase 1 trial safety tabulation to show significant digits only

hyper_mtdi_lognormal-class

Hyperprior for lognormal MTDi distributions

mtdi_lognormal-class

A lognormal MTDi distribution

ordinalizer

Ordinalizers

phase1_sim

Override escalation:::phase1_sim to incorporate latent toxicity tolerances

plan

Plan

plot-mtdi_distribution-ANY-method

Visualize an mtdi_distribution object

plot-mtdi_generator-ANY-method

Visualize n samples from an mtdi_generator object

precautionary-package

Safety Diagnostics for Dose-Escalation Trial Designs

print.exact

Specialize print method for objects of class simulations

print.hyper

Specialize print method defined for class simulations

print.precautionary

Specialize print method for objects of class simulations

safety_kable

Output a kable for a simulation summary of class safetytab

simulate_trials

Simulate trials defined via package escalation

simulation_function.u_i

Get a function that simulates dose-escalation trials using latent u_i

summary.exact

Summarize an exact treatment of a dose-escalation design

summary.precautionary

Specialize a method defined in package 'escalation' for class 'simulations'

test_draw_samples

Test performance of draw_samples function

viola_dtp

Complete dose transition pathways (DTP) table for the VIOLA trial.

precautionary

Safety Diagnostics for Dose-Escalation Trial Designs

v0.2-1
MIT + file LICENSE
Authors
David C. Norris [aut, cre, cph] (<https://orcid.org/0000-0001-9593-6343>), Markus Triska [ctb]
Initial release
2021-01-12

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