Calculate dose-transition pathways for an EffTox study
Calculate dose-transition pathways for an EffTox study. Note that TODO TODO TODO
efftox_dtps_to_dataframe(dat, cohort_sizes, next_dose, ...)
dat |
An instance of |
cohort_sizes |
vector of future cohort sizes, i.e. positive integers.
E.g. To calculate paths for the the next cohort of two followed by another
cohort of three, use |
next_dose |
the dose-level to be given to the immediately next cohort. |
... |
extra params passed to |
dose pathways in a data.frame.
Brock K, Billingham L, Copland M, Siddique S, Sirovica M, Yap C. Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology. 2017;17(1):112. doi:10.1186/s12874-017-0381-x
# Calculate the paths for the first cohort of 3 in Thall et al 2014 example
dat <- efftox_parameters_demo()
## Not run:
dtps1 <- efftox_dtps_to_dataframe(dat = dat, cohort_sizes = c(3),
next_dose = 1)
## End(Not run)
# To calculate future paths in a partially-observed trial
dat <- efftox_parameters_demo()
dat$doses = array(c(1,1,1))
dat$eff = array(c(0,0,0))
dat$tox = array(c(1,1,1))
dat$num_patients = 3
## Not run:
dtps2 <- efftox_dtps_to_dataframe(dat = dat, cohort_sizes = c(3),
next_dose = 1)
## End(Not run)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.