Get the Prob(Tox) for Prob(Eff) and utility pairs
Get the probability of toxicity for probability-of-efficacy and utility pairs
efftox_get_tox(eff, util, p, eff0, tox1)
eff |
Probability of efficacy; number between 0 and 1 |
util |
Utility score; number |
p |
p-index of EffTox utility contours. Use |
eff0 |
Efficacy probability required when toxicity is impossible; a number between 0 and 1 |
tox1 |
Toxicity probability permitted when efficacy is guaranteed; a number between 0 and 1 |
Probability(s) of toxicity
Various ways of vectorising the function are demonstrated in the examples
p <- efftox_solve_p(0.5, 0.65, 0.7, 0.25)
prob_tox <- efftox_get_tox(0.7, 0, p, eff0 = 0.5, tox1 = 0.65)
round(prob_tox, 2) == 0.25
prob_tox <- efftox_get_tox(0.7, seq(-0.5, 0.25, by = 0.25), p, eff0 = 0.5,
tox1 = 0.65)
round(prob_tox, 2) == c(0.57, 0.41, 0.25, 0.09)
prob_tox <- efftox_get_tox(c(0.5, 0.7, 0.8), 0.25, p, eff0 = 0.5, tox1 = 0.65)
round(prob_tox, 2) == c(NaN, 0.09, 0.22)
prob_tox <- efftox_get_tox(c(0.5, 0.7, 0.8), c(-1, 0, 1), p, eff0 = 0.5,
tox1 = 0.65)
round(prob_tox, 2) == c(0.63, 0.25, NaN)Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.