vpc: pk_iv_1cmt – R documentation

Pricing

Become an expert in R — Interactive courses, Cheat Sheets, certificates and more!

Get Started for Free

Documentation

vpc

pk_iv_1cmt

Simulate PK data from a 1-compartment iv model

Description

Simulate PK data from a 1-compartment iv model

Usage

pk_iv_1cmt(
  t,
  t_inf = 1,
  tau = 24,
  dose = 120,
  CL = 0.345,
  Vc = 1.75,
  ruv = NULL
)

Arguments

`t`	Time after dose
`t_inf`	Infusion length
`tau`	Dosing interval
`dose`	Dose
`CL`	Clearance
`Vc`	Volume of distribution
`ruv`	Residual variability

Value

A vector of predicted values, with or without added residual variability

Examples

dat1 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50)
dat2 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50, 
                   ruv = list(proportional = 0.1, additive = 0.1))

vpc

Create Visual Predictive Checks

v1.2.2

MIT + file LICENSE

Authors

Ron Keizer <ronkeizer@gmail.com>

Initial release

2021-01-11