Representing Big Stick Design
Represents the randomization procedure Big Stick Design.
bsdPar(N, mti, groups = LETTERS[1:2])
N |
integer for the total sample size of the trial. |
mti |
maximum tolerated imbalance in patient numbers during the trial. |
groups |
character vector of labels for the different treatments. |
Tossing a fair coin as long as the difference in group sizes does not
exceed the mti. If the mti is reached a deterministic
allocation is done, so that the difference in group sizes is reduced.
S4 object of the class bsdPar.
J. F. Soares and C. F. Jeff Wu (1983) Some Restricted Randomization Rules in Sequential Designs. Comm. in Stat., 12, 2017-34.
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