Representing Chen's Design
Represents the randomization procedure Chen's Design.
chenPar(N, mti = N, p = 0.5, groups = LETTERS[1:2])
N |
integer for the total sample size of the trial. |
mti |
maximum tolerated imbalance in patient numbers during the trial. |
p |
success probability of the biased coin (e.g. in Efron's Biased Coin Design). |
groups |
character vector of labels for the different treatments. |
Flip a biased coin with probability p in favor of the treatment
which is allocated less frequently as long as the difference in group sizes does
not exceed the mti. If the mti is reached a deterministic
allocation is done, so that the difference in group sizes is reduced.
If both treatments have been assigned equally often a fair coin is tossed.
S4 object of the class chenPar.
Chen Yung-Pin (1999) Biased coin design with imbalance tolerance. Comm. in Stat., 15, 953-975.
Please choose more modern alternatives, such as Google Chrome or Mozilla Firefox.