randomizeR: mpPar – R documentation

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randomizeR

mpPar

Representing Maximal Procedure

Description

Represents the Maximal Procedure.

Usage

mpPar(N, mti, ratio = c(1, 1), groups = LETTERS[1:2])

Arguments

`N`	integer for the total sample size of the trial.
`mti`	maximum tolerated imbalance in patient numbers during the trial.
`ratio`	vector of length `K`. The total sample number `N` and all used block lengths (`bc`) have to be divisible by `sum(ratio)`.
`groups`	character vector of labels for the different treatments.

Details

Fix the total sample size N and the mti. Afterwards, the patients are assigned to each treatment arm according to the ratio. All randomization sequences are equiprobable.

Value

S4 object of the class mpPar.

References

V.W. Berger, A. Ivanova and M.D. Knoll (2003) Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Statistics in Medicine, 19, 3017-28.